On January 15, 2013, I presented the proposed world-class health care system (WCHS) project in Akwa Ibom state, Nigeria to faculty fellows of the Center for Health Systems & Design, at the College of Architecture, Texas A&M University. Details of the proposed project appear elsewhere. The purpose of the presentation was to solicit input about how we can apply evidence based practice in the design, development and implementation of the WCHS. The goal of the project is to create a destination medical city that would serve needs of local communities and international clientele. The envisioned product is the Thompson & Grace Medical University (TGMU), built on a master-planned medical city (Thompson & Grace Medical City [TGMC]), and serving a series of ambulatory care centers distributed within the state of Akwa Ibom.